Tufty: You Will Never Look at a Teddy Bear the Same Way Ever Again

You probably had a teddy bear as a kid, or some other stuffed animal. We all did. There's nothing wrong with that, right? Not here in the real world (probably) but according to the short film Tufty, you've got some blood on your hands. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/KKONfyr_uKE/tufty-you-will-never-look-at-a-teddy-bear-the-same-way-ever-again

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Experts: Code on WWII carrier pigeon unbreakable

A World War II code delivered by carrier pigeon is stumping today's cypher specialists. Can you break it? NBC's Brian Williams reports.

By Ian Johnston, NBC News

LONDON ? A coded message from World War II found on the leg of a dead carrier pigeon in an English chimney cannot be deciphered, according to British intelligence agents.

The handwritten message on a small sheet of paper headed "Pigeon Service" was found earlier this month in a small red canister still attached to the pigeon's leg,?the GCHQ agency said in a statement posted on its website.

The pigeon is thought to have been one of the 250,000 used by British forces ? including secret agents working behind enemy lines in German-occupied Europe ? during the 1939-1945 war.


The message was signed and appears to say "Sjt W Stot", GCHQ said, adding that nothing is known of this individual or their unit. Sjt is an abbreviation of the old-fashioned "serjeant" spelling of the army rank.

Royal Pigeon Racing Association, courtesy Bletchley Park Trust

This coded message from World War II was found in a canister still attached to the leg of a dead carrier pigeon.

'Tribute' to code-makers
It was destined for a place code-named "X02," but it is also not known what this means.?It contains 27 five-letter code groups, but GCHQ said it was impossible to decipher the message without the relevant code book.

"During the war, the methods used to encode messages naturally needed to be as secure as possible and various methods were used," the agency's statement said.

"The senders would often have specialist code books in which each code group of four or five letters had a meaning relevant to a specific operation, allowing much information to be sent in a short message. For added security, the code groups could then themselves be encrypted," it said.

"Although it is disappointing that we cannot yet read the message brought back by a brave carrier pigeon, it is a tribute to the skills of the wartime code-makers that, despite working under severe pressure, they devised a code that was undecipherable both then and now," it added.

Courtesy Bletchley Park Trust

This coded message from World War II was found in a canister still attached to the leg of a dead carrier pigeon.

It is thought a "one-time pad" may have been used to encrypt the message.

"The advantage of this system is that, if used correctly, it is unbreakable as long as the key is kept secret. The disadvantage is that both the sending and receiving parties need to have access to the same key, which usually means producing and sharing a large keypad in advance," GCHQ said.

The pigeons carried a wide variety of messages, "flying the gauntlet of enemy hawk patrols and soldiers taking potshots at them to bring vital information back to Britain from mainland Europe," GCHQ added.

Each had its own identity number and the Bletchingley message contains two such numbers ? NURP.40.TW.194 and NURP.37.OK.76. Either could be the dead pigeon's number.

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Source: http://worldnews.nbcnews.com/_news/2012/11/23/15384954-uk-experts-code-found-on-world-war-ii-carrier-pigeon-is-unbreakable?lite

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Halle Berry's ex headed to court after Thanksgiving brawl

LOS ANGELES (Reuters) - The father of Halle Berry's daughter is headed to court after he was arrested following a fistfight with her fianc? outside the Oscar winning actress' Los Angeles home on Thanksgiving, police said.

Canadian model Gabriel Aubry, 37, was later released on $20,000 bail after being charged with misdemeanor battery following the punch-up with Berry's fianc?, French actor Olivier Martinez, 46, in the driveway of her house on Thursday.

The altercation occurred during a custodial hand-off involving Berry's 4-year-old daughter with Aubry, Nahla, according to Los Angeles police officer Julie Boyer.

Following the scuffle, Aubry and Martinez were both taken to Cedars-Sinai Medical Center with "non-life-threatening injuries," Boyer said. Aubry is due to appear in court on December 13.

Berry, 46, who won a best actress Oscar for her role in 2001 film "Monster's Ball," has been embroiled in a bitter custody battle with Aubry since they broke up in April 2010. Earlier this month, a judge denied Berry's request to move to France with Nahla.

Berry and Martinez met while filming the movie "Dark Tide." They announced their engagement in March.

A judge has since issued an emergency protective order requiring Aubry to stay at least 100 yards (meters) from Berry, their daughter and Martinez, according to celebrity website, TMZ.com.

(Reporting by Tim Gaynor; Editing by Sandra Maler)

Source: http://news.yahoo.com/halle-berrys-ex-headed-court-thanksgiving-brawl-183442682.html

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Exclusive Black Friday Deals For Gizmodo Readers Only

You can save a bundle on Black Friday and Cyber Monday, but oftentimes to get the best savings you have to settle for a gadget that's not necessarily exactly what you want just because it's deeply discounted. So Dealzmodo went out and scored Black Friday savings for Gizmodo readers on cool stuff that you actually want. You're welcome, and enjoy. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/oWzC3ZNjDVY/exclusive-black-friday-deals-for-gizmodo-readers-only

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Small Business Saturday in Austin | PR by the Book

POSTED BY prbythebook ON November 23, 2012

In case you haven?t heard of Small Business Saturday yet, it?s a new annual event that takes place every November between Black Friday and Cyber Monday. Created by American Express, the day encourages shoppers to go local for all of their shopping needs.

Living in Austin, TX the small business culture is strong. In fact, as an Austinite, you might recognize most of the stores in the commercial for Small Business Saturday last year:

We too, are a small business in Austin. We just celebrated 10 years in business and are happy to be operating in such a vibrant town for entrepreneurs. The community around us is a great source for resources and support (and we are certainly thankful for them this holiday). Here are a few other local businesses we?re connected to. If you?re an Austinite, make sure you support them this Saturday:

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Monkey Mat
Christie Barany created her very own solution to the nightmare of finding a clean surface for her kids to play on: Monkey Mat. It?s a highly portable blanket that is water resistant and easy to clean. Useful in all playful and practical situations, Monkey Mat is great for outdoors and indoors. (Plus, it?s a? great gift for moms if you?re shopping this weekend.)

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Discount Thief
Donna L. Johnson is a local fashionista who has made it her mission to save our closets and our wallets. If you could use a daily dose of fashion tips, blogging tips, or just a daily dose of funny, make sure you follow her on Twitter, @DiscountThief.

Physician?s Way
Dr. Richard Kelley is the co-founder of Physician?s Way, a local weight-loss and health management program. Dr. Kelley helps individuals meet their health and fitness goals and one of the latest tools he?s created to help is the book, The Fitness Response.

What are some small businesses you?ll support this weekend?

Tags: Austin, entrepreneurs, shopping, Small Business Saturday

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Source: http://www.prbythebook.com/small-business-saturday-in-austin/?utm_source=rss&utm_medium=rss&utm_campaign=small-business-saturday-in-austin

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ScienceDaily: Gene News

http://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usSat, 24 Nov 2012 05:54:25 ESTSat, 24 Nov 2012 05:54:25 EST60
Media_httpwwwscienced_ufpho
http://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.http://www.sciencedaily.com/releases/2012/11/121123092132.htm The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system scientists have shown that the genome of this virus contains much more information than previously assumed. The researchers identified several hundred novel proteins, many of which were surprisingly small.Fri, 23 Nov 2012 09:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121123092132.htmhttp://www.sciencedaily.com/releases/2012/11/121122152928.htm Scientists have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to ?see? one of influenza?s essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus?s vulnerabilities that are sure to be of interest to drug developers.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152928.htmhttp://www.sciencedaily.com/releases/2012/11/121122152910.htm Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152910.htmhttp://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmhttp://www.sciencedaily.com/releases/2012/11/121121130811.htm Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a new study. The study reveals a biomarker that can predict responses to cancer drugs and offers a strategy to treat drug-resistant tumors based on their genetic signature.Wed, 21 Nov 2012 13:08:08 ESThttp://www.sciencedaily.com/releases/2012/11/121121130811.htmhttp://www.sciencedaily.com/releases/2012/11/121121130703.htm Two recent studies delve into the role of chromatin modifying enzymes and transcription factors in tumour cells. In one, it was found that the PARP1 enzyme activated by kinase CDK2 is necessary to induce the genes responsible for the proliferation of breast cancer cells in response to progesterone. In another, extensive work has been undertaken to identify those genes activated by the administration of progesterone in breast cancer, the sequences that can be recognized and how these genes are induced.Wed, 21 Nov 2012 13:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121121130703.htmhttp://www.sciencedaily.com/releases/2012/11/121121130643.htm Previously discarded, human-specific ?junk? DNA represents untapped resource in the study of diseases like Alzheimer?s and autism.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130643.htmhttp://www.sciencedaily.com/releases/2012/11/121121130633.htm In a new study, researchers describe markers and a model that quantify how aging occurs at the level of genes and molecules, providing not just a more precise way to determine how old someone is, but also perhaps anticipate or treat ailments and diseases that come with the passage of time.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130633.htmhttp://www.sciencedaily.com/releases/2012/11/121121104552.htm New research has found there are several different ways that kidney tumors can achieve the same result -- namely, grow.Wed, 21 Nov 2012 10:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121121104552.htmhttp://www.sciencedaily.com/releases/2012/11/121121104416.htm Clumped proteins can be dissolved with the aid of cellular repair systems -- a process of critical importance for cell survival especially under conditions of stress. Researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104416.htmhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmhttp://www.sciencedaily.com/releases/2012/11/121120194932.htm A new rapid test for tuberculosis (TB) could substantially and cost-effectively reduce TB deaths and improve treatment in southern Africa -- a region where both HIV and tuberculosis are common.Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194932.htmhttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmhttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmhttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htmhttp://www.sciencedaily.com/releases/2012/11/121120084725.htm Scientists have uncovered evidence that the gene FTO ? the major genetic contributor to obesity ? is associated with an eight per cent reduction in the risk of depression.Tue, 20 Nov 2012 08:47:47 ESThttp://www.sciencedaily.com/releases/2012/11/121120084725.htmhttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmhttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htmhttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmhttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmhttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htmhttp://www.sciencedaily.com/releases/2012/11/121117184658.htm A new discovery concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.Sat, 17 Nov 2012 18:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121117184658.htmhttp://www.sciencedaily.com/releases/2012/11/121116161059.htm Adverse side effects of certain hepatitis C medications can now be replicated in the lab, thanks to a research team. The new method aids understanding of recent failures of hepatitis C antiviral drugs in some patients, and could help to identify medications that eliminate adverse effects. The findings may aid the development of safer and more effective treatments for hepatitis C and other pathogens such as SARS and West Nile virus.Fri, 16 Nov 2012 16:10:10 ESThttp://www.sciencedaily.com/releases/2012/11/121116161059.htmhttp://www.sciencedaily.com/releases/2012/11/121116124644.htm Researchers have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.Fri, 16 Nov 2012 12:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121116124644.htmhttp://www.sciencedaily.com/releases/2012/11/121116124551.htm New research shows that a gene is responsible for a person's tendency to be an early riser or night owl -- and helps determine the time of day a person is most likely to die.Fri, 16 Nov 2012 12:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121116124551.htmhttp://www.sciencedaily.com/releases/2012/11/121116091226.htm Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.Fri, 16 Nov 2012 09:12:12 ESThttp://www.sciencedaily.com/releases/2012/11/121116091226.htmhttp://www.sciencedaily.com/releases/2012/11/121115210541.htm Researchers have pieced together new genetic clues to the arthritis puzzle in a study that brings potential treatments closer to reality and could also provide insights into why more women than men succumb to the disabling condition.Thu, 15 Nov 2012 21:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121115210541.htmhttp://www.sciencedaily.com/releases/2012/11/121115172255.htm Passing one's genes on to the next generation is a mark of evolutionary success. So it makes sense that the body would work to ensure that the genes the next generation inherits are exact replicas of the originals. Biologists have now identified one way the body does exactly that.Thu, 15 Nov 2012 17:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121115172255.htmhttp://www.sciencedaily.com/releases/2012/11/121115152655.htm Researchers report that an efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease.Thu, 15 Nov 2012 15:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115152655.htmhttp://www.sciencedaily.com/releases/2012/11/121115133414.htm For the past several years, research has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. In a new study, scientists have shown that this enzyme can actually also work in another fundamental process in humans.Thu, 15 Nov 2012 13:34:34 ESThttp://www.sciencedaily.com/releases/2012/11/121115133414.htmhttp://www.sciencedaily.com/releases/2012/11/121115133312.htm Researchers have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis.Thu, 15 Nov 2012 13:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121115133312.htmhttp://www.sciencedaily.com/releases/2012/11/121115132903.htm Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132903.htmhttp://www.sciencedaily.com/releases/2012/11/121115132901.htm Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132901.htmhttp://www.sciencedaily.com/releases/2012/11/121115132613.htm New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.Thu, 15 Nov 2012 13:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115132613.htmhttp://www.sciencedaily.com/releases/2012/11/121115132344.htm Thanks to some careful detective work, scientist better understand just how iPS cells form ? and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132344.htmhttp://www.sciencedaily.com/releases/2012/11/121115132342.htm About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study has shown.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132342.htmhttp://www.sciencedaily.com/releases/2012/11/121114172833.htm Relatively small levels of exposure to alcohol while in the womb can influence a child's IQ, according to a new study using data from over 4,000 mothers and their children.Wed, 14 Nov 2012 17:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121114172833.htmhttp://www.sciencedaily.com/releases/2012/11/121114171710.htm A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team of researchers. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171710.htmhttp://www.sciencedaily.com/releases/2012/11/121114171708.htm For the first time, researchers have landed on a potential diagnostic method to identify at least a subset of patients with chronic fatigue syndrome - testing for antibodies linked to latent Epstein-Barr virus reactivation.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171708.htmhttp://www.sciencedaily.com/releases/2012/11/121114153227.htm In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin.Wed, 14 Nov 2012 15:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114153227.htmhttp://www.sciencedaily.com/releases/2012/11/121114134512.htm Researchers provide a whole-genome sequence and analysis of number of pig breeds, including a miniature pig that serves a model for human medical studies and therapeutic drug testing.Wed, 14 Nov 2012 13:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121114134512.htmhttp://www.sciencedaily.com/releases/2012/11/121114134054.htm Caterpillar fungi are rare parasites found on hibernating caterpillars in the mountains of Tibet. For centuries they have been highly prized as a traditional Chinese medicine - just a small amount can fetch hundreds of dollars.Wed, 14 Nov 2012 13:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121114134054.htmhttp://www.sciencedaily.com/releases/2012/11/121114113803.htm There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.Wed, 14 Nov 2012 11:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121114113803.htmhttp://www.sciencedaily.com/releases/2012/11/121114113235.htm New research has uncovered the cause of infertility for 80 per cent of couples previously diagnosed with 'unexplained infertility': high sperm DNA damage.Wed, 14 Nov 2012 11:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114113235.htmhttp://www.sciencedaily.com/releases/2012/11/121114083928.htm The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.Wed, 14 Nov 2012 08:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121114083928.htmhttp://www.sciencedaily.com/releases/2012/11/121113214635.htm For the first time, researchers have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. Researchers used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This assisted in stopping the outbreak earlier, saving possible harm to patients. This approach is much more accurate than current methods used to detect hospital outbreaks.Tue, 13 Nov 2012 21:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121113214635.htmhttp://www.sciencedaily.com/releases/2012/11/121113161506.htm Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such as hip fracture, heart attack, cancer, and death.Tue, 13 Nov 2012 16:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121113161506.htmhttp://www.sciencedaily.com/releases/2012/11/121113143656.htm Biologists have discovered that fats within cells store a class of proteins with potent antibacterial activity, revealing a previously unknown type of immune system response that targets and kills bacterial infections.Tue, 13 Nov 2012 14:36:36 ESThttp://www.sciencedaily.com/releases/2012/11/121113143656.htmhttp://www.sciencedaily.com/releases/2012/11/121113134807.htm Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.Tue, 13 Nov 2012 13:48:48 ESThttp://www.sciencedaily.com/releases/2012/11/121113134807.htmhttp://www.sciencedaily.com/releases/2012/11/121113134230.htm The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell?s powerhouse, making it dependent on the amino acid glutamine for survival. Depriving cells of glutamine selectively induces programmed cell death in cells overexpressing mutant Myc. Using Myc-active neuroblastoma cells, a team three priotein executors of the glutamine-starved cell, representing a downstream target at which to aim drugs. Roughly 25 percent of all neuroblastoma cases are associated with Myc-active cells.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134230.htmhttp://www.sciencedaily.com/releases/2012/11/121113134224.htm Even the very lowest levels of radiation are harmful to life, scientists have concluded, reporting the results of a wide-ranging analysis of 46 peer-reviewed studies published over the past 40 years. Variation in low-level, natural background radiation was found to have small, but highly statistically significant, negative effects on DNA as well as several measures of health.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134224.htmhttp://www.sciencedaily.com/releases/2012/11/121113122220.htm Scientists have discovered a new gene that regulates heme synthesis in red blood cell formation. Heme is the deep-red, iron-containing component of hemoglobin, the protein in red blood cells responsible for transporting oxygen in the blood. The findings promise to advance the biomedical community's understanding and treatment of human anemias and mitochondrial diseases, both known and unknown.Tue, 13 Nov 2012 12:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121113122220.htmhttp://www.sciencedaily.com/releases/2012/11/121113122133.htm Researchers have tracked a gene's crucial role in orchestrating the placement of neurons in the developing brain. Their findings help unravel some of the mysteries of Joubert syndrome and other neurological disorders.Tue, 13 Nov 2012 12:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121113122133.htmhttp://www.sciencedaily.com/releases/2012/11/121113091953.htm Why do we get older? When do we die and why? Is there a life without aging? For centuries, science has been fascinated by these questions. Now researchers have examined why the polyp Hydra is immortal -- and unexpectedly discovered a link to aging in humans.Tue, 13 Nov 2012 09:19:19 ESThttp://www.sciencedaily.com/releases/2012/11/121113091953.htm

Source: http://www.sciencedaily.com/rss/health_medicine/genes.xml

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Early Adopter: Build This Knock Hockey Table

DEGREE OF DIFFICULTY: 5/10
AGES: 8+
BUILD TIME: 2 Hours
PARTS COST: About $40

PARTS/CUT LIST


? One 2 x 4?foot piece of smooth ?-inch plywood (base); the project shown here uses birch, but you may choose to use maple or even pine, provided the surface is level and uniform
? 2 pieces of 1 x 4 pine, 48 inches long (long rails)
? 2 pieces of 1 x 4 pine, 25? inches long (short rails; the arched goals will be cut out of these rails)
? Two 3?-inch squares of 1 x 4 pine; these are cut in half diagonally to form the corner bumpers
? Two 1?-inch squares cut from 1 x 4 pine (goal blocks)
? One 2?-inch-diameter circular piece cut from 1 x 4 pine (puck)
? Two 12-inch-long pieces of 1 x 4 pine cut to desired shape and size for hockey sticks

PREP THE BASE, CUT OUT THE GOALS, AND ATTACH ONE SHORT RAIL


1. Use fine (120-grit) sandpaper to smooth out any sharp edges or corners on the base. Prime the top, bottom, and sides with latex paint and let dry. Add two light coats of colored gloss paint to one side of the base and let dry. We chose a bright blue spray paint. You may opt for a brush or roller; just be sure that the finishing coat is uniform so that the playing surface is slick.

2. On the center of the face of each short rail, make marks ? inch from the bottom and 1 inch from the top. Place additional marks 2? inches on either side of the bottom-center spot. Draw a line connecting the three marks along the bottom of each short rail, and then freehand an arc connecting the ends of that line with the top-center mark. These are the goal outlines. Drill ?-inch pilot holes at the end of each line, then cut out the goals.

3. Apply beads of wood glue along the bottom of the inside face of one short rail and along one short edge of the base. Center and press the rail against the base. Drill two 1/16-inch pilot holes about 2 inches from the outer edges of the goal, ? inch from the bottom of the rail. Drive 1?-inch 4d galvanized nails into the pilot holes.

ATTACH THE LONG RAILS, SECOND SHORT RAIL, AND CORNER BUMPERS


1.Apply beads of glue to the bottom and one end of one long rail, and to the edge of the short rail protruding to the side of the base. Press the long rail against the base and the short rail. Drill four pilot holes through the rail into the base. Add three more pilot holes vertically along the edge of the short rail into the end of the long rail. Nail the long rail into place. Repeat on the other side.

2.Attach the second short rail, using the same method as above. Glue the corner bumpers into the corners.

AFFIX THE GOAL BLOCKS, AND PAINT THE BLUE LINES


1. Mark a spot 9 inches from each short rail, on center with the goal. Apply glue to the bottom of each goal block, and place one corner flush with each spot. Drill two ?-inch pilot holes through each block into the base, and drive a ?-inch No. 8 screw into each hole.

2. Make two marks 18 inches from each short rail, and mask off a ?-inch space to the side of each mark. Paint, let dry, remove tape.

Source: http://www.popularmechanics.com/technology/gadgets/toys/early-adopter-build-this-knock-hockey-table-14774066?src=rss

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Finance Ministry seeks Bt70bn more for rice pledging scheme: TDRI ...

Home ? breakingnews ? Finance Ministry seeks Bt70bn more for rice pledging scheme: TDRI

November 22, 2012 5:57 pm

Nipon Poapongsakorn, a distinguished TDRI scholar, said Thursday that a letter from the ministry has explained to the government that the ministry has to have another Bt70billion budget for the rice pledging scheme. He urged the government to reveal full information on the rice pledging scheme.

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Source: http://www.nationmultimedia.com/breakingnews/Finance-Ministry-seeks-Bt70bn-more-for-rice-pledgi-30194842.html

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95% Diana Vreeland: The Eye Has To Travel

All Critics (58) | Top Critics (24) | Fresh (55) | Rotten (3)

Her life, and her work, transcended what we think of as "fashion." Diana Vreeland: The Eye Has to Travel celebrates a unique and uniquely determined woman.

Many people remember some of Diana Vreeland's famous pronouncements ("I adore pink! It is the navy blue of India!") but few remember actually hearing her speak. The documentary Diana Vreeland: The Eye Has to Travel takes care of that.

For fashionphiles and pop culture vultures, there's much to devour.

Diana Vreeland is both history lesson and sentimental love letter to a fashion titan.

Legendary fashion editor Diana Vreeland was the consummate dreamer, a romantic who never looked back and propelled society forward.

A feast for fashion-history buffs and anyone who applauds unstoppable eccentricity.

...more of an energetic and affectionate sketch than a revealing portrait of this oversized personality, but one has to wonder if the woman who celebrated glittering surfaces would have wanted it any other way.

This fascinating documentary reveals that Vreeland (who died in 1989, aged 86) was an original: a dynamic woman with energy to spare and an infectious lust for life

What makes this such a joy to watch is not just the timeline of fashion highlights, but Vreeland's unique perspective on life.

The filmmakers have done a fine job corralling so many fantastic tales from Vreeland's life.

"Diana Vreeland: The Eye Has to Travel" is an intriguing portrait of a true original; you only wish the movie had half the color and verve of its subject.

A lively movie, and in the case of its appearance-obsessed subject, it feels right that all it does is skim the surface.

[Vreeland's] influence on twentieth-century culture was large, and it's celebrated here with affection, dedication and skill--but very little critical detachment.

Though unwilling to dig too deeply into what seems an imperfect private life, it still serves as a splendid introduction to a unique personality.

A poignant portrait of an inveterate iconoclast who couldn't help but push the envelope.

[A] warm portrait of the world's first true fashion maven.

It can be hard to keep up at points -- not with the plot, but with the amount of inspiration that Diana can still strew over an audience.

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Source: http://www.rottentomatoes.com/m/diana_vreeland_the_eye_has_to_travel_2012/

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Guest Post: Getting Schooled on Developing the Best Games for ...

Editor?s note: The following guest post was written by?Peter Hofstede, the Game Development Director at Spil Games. Spil is billed as the largest independent online gaming platform. As the social games market grows more crowded, developers find themselves competing more and more for audience share. One group that hasn?t been targeted by most studios are in the tween demographic, an audience that Spil?s found success with via its Girls Go Games label. In this article, Hofstede offers advice on how to find success with tweens.

There are over 80 million social games played each day, yet only 15 percent of these games are played more than once by a user. We?re seeing a high level of abandonment in the social gaming space, but keep in mind that many of these games are developed for mass audiences? where it?s very difficult to please everyone. At Spil Games, we prefer to operate in a world where tailoring gaming experiences to niche audiences is an ideal way to reach an engaged consumer base and convert them into loyal users.

Thinking specifically about tween girls, teenage boys or even parents looking to play online games with their kids, developing games for niche audiences can provide a major growth opportunity. If fact, 91 percent of kids are gamers ? we know the market is there ? it?s simply a matter harnessing these consumers to get them to play your game. When it comes to success, it is crucial for developers to incorporate a user-centered design approach to appeal to niche audiences? unique interests and behaviors. Getting it right doesn?t require a PhD in psychology, and while it certainly couldn?t hurt, there are several different tactics to understanding the basics throughout the game development process.

I think of it as a three-step design approach:

1. Understand the psychological foundations of the audience for which you are developing.

2. Use focus groups to double-check your findings

3. Validate your game by testing it on real users.

Let?s dive deeper ?

I. Open your Textbooks: Psych 101

Before you can get into your audiences? hands, first things first: Get inside their heads. Specific to the teen and tween demographic, it?s essential to know the basic psychology behind these players so that they will find your game content engaging. In other words: Don?t trust your own ?grown up? intuition. The psychology behind gameplay is fascinating to read up on. The incorporation of psychological phenomena, such as a positive feedback loop (continuing an action or behavior because of the reoccurring positive outcome,) for example, has been shown to influence gaming behavior by extending average length of play and recurring gameplay.

It is also important to examine gender differences when developing games to niche audiences. We find that there are many game components that motivate kids in general, but we also see that boys and girls tend to be motivated by different aspects of games, especially for players that fall between the ages of 6-12. For example, younger teenage boys prefer games that are extreme, with winners and losers, and an overtly competitive component where they can clearly show off results.

Tween girls like competition as well, but are also interested in non-competitive gameplay that helps them to develop self-esteem and feelings of self-worth. Tween girls are also at an age where they are eager to act out different roles they see exhibited in their daily lives. Understanding that they see their daily role models (parents, older siblings, etc.) duties like feeding household pets and being held accountable for a fulltime job could all translate into successful online game themes.

II. Pop Quiz: Implementing Checklists and Focus Groups in Game Creation

Of course, not everything can be learned from textbooks, or rather, initial psychological or behavioral research. It is just as important to incorporate a human component to the development process by taking a look at focus group reactions, survey findings and direct feedback from niche audiences into making a game as awesome as possible.

In this phase of the game development process, think of your gamers as co-developers, aiding you in fully baking out the perfect game. Surveys and focus groups are the perfect way to test out a brand new game or character and see a small-scale perspective of how your audience will react.

A great focus group example is when we were tasked to rebrand and update a character in one of our staple franchises. The goal was to modernize the female chef character of a cooking game. After several focus groups in Europe, working with hundreds of tween gamers and their parents to determine their thoughts and reactions to the chef character, we ended up fully revamping her wardrobe, hair and makeup to appeal to these tween girls and their parents.

III. Physical Education: Designing User-Interface around Niche Audience?s Anatomy

In phase three of the game development process, that is, having real gamers play completed games in the lab, we have found an essential aspect of developing a game is all too easily forgotten: audience specific usability issues. For instance, with little gamers come little fingers. As a developer, we need to make sure that we are not only creating games kids will love, but also making sure that they can actually play them. The size of these gamers? hands and fingers directly impact the way they type, hold a mouse and play games on a smartphone or ? minor details which can ultimately impact whether a kid loves your game, or wants to throw their dad?s smartphone out the car window!

Specifically, our usability tests reveal several findings. One demonstrated younger kids find holding a tablet device to be very difficult for their little hands. In an attempt to grasp the tablet, the children often accidentally touch the screen with their fingers, which impacts the game controls. Developers can implement more forgiving touch systems to combat this issue, for example by placing the finger closest to a button or active region in control and have all other finger pressure ignored.

Graduation:

We are witnessing a very exciting time for the gaming space but for a developer to survive in this highly populated world, it is essential to take the necessary steps to understand audience behavior. Understanding specific audience preferences and behavior can not only instill confidence in a game?s success post-development, but also help developers allocate resources appropriately throughout the entire process. Developers can use data from focus groups and usability tests to prioritize what to spend the most time on during the creation process. There?s no need to spend hours refining certain animation details if you know your target audience cares more about the potential ways they can customize the game. There are plenty of hit games yet to be developed, we just need to make sure to hone in on the most applicable aspects to incorporate, so that awesome games can reach audiences effectively and start earning return.

Source: http://www.insidesocialgames.com/2012/11/23/guest-post-attention-game-developers-getting-schooled-on-developing-the-best-games-for-teens-and-tweens/

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