Four Crafts to Get Crafting! - Fairchild Family Housing - epeyrcytu's ...

Crafting is having quite a resurgence, and many are forgoing TV time to work on homespun projects. If you?re looking for a new hobby, check out this list of crafts that offer productive and fun ways to spend your leisure time.

-??????? Knitting is one of the most popular craft hobbies today. The supplies are inexpensive and very portable ? you can easily carry your yarn and needles in your purse and take them out whenever you have time. You can also work on projects in short periods of time, like during a commute or while in a waiting room.

-??????? Origami is an ancient and lovely crafting choice. The Japanese art of folded paper can make some awesome shapes if you keep at it. An inexpensive hobby, all you really need are square sheets and instructions.?

-??????? Quilting has become increasingly recent years, as people are recognizing the artistic expression possible in these traditional blankets. Though it's not portable, the end product can be spectacular and very useful.

-??????? Screen printing is now easier than ever to do at home. You can purchase a one-piece kit at a craft store that lets you expose an image, burn a screen, and print on paper, fabric, or other materials quickly and easily. This simple?method is loads of fun and makes great gifts for family and friends.

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Source: http://blog.fairchildfamilyhousing.com/2012/12/13/four-crafts-to-get-crafting/

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Personalized Cancer Medicine: Drugs Based On Genetics Alone ...


By Sharon Begley
NEW YORK, Dec 13 (Reuters) - The cancer cells were not behaving the way the textbooks say they should. Some of the cells in colonies that were started with colorectal tumor cells were propagating like mad; others were hardly multiplying. Some were dropping dead from chemotherapy and others were no more slowed by the drug than is a tsunami by a tissue. Yet the cells in each "clone" all had identical genomes, supposedly the all-powerful determinant of how cancer cells behave.
That finding, published online Thursday in Science, could explain why almost none of the new generation of "personalized" cancer drugs is a true cure, and suggests that drugs based on genetics alone will never achieve that holy grail.
Scientists not involved in the study praised it for correcting what Dr. Charis Eng, an oncologist and geneticist who leads the Genomic Medicine Institute at the Cleveland Clinic, called "the simple-minded" idea that tumor genomes alone explain cancer.
Calling the study "very exciting," she said the finding underlines that a tumor's behavior and, most important, its Achilles heel depend on something other than its DNA. Her own work, for instance, has shown that patients with identical mutations can have different cancers.
The core premise of the leading model of cancer therapy is that cells become malignant when they develop mutations that make them proliferate uncontrolled. Find a molecule that targets the "driver" mutation, and a pharmaceutical company will have a winner and patients will be cancer-free.
That's the basis for "molecularly targeted" drugs such as Pfizer 's Xalkori for some lung cancers and Novartis 's Gleevec for chronic myeloid leukemia. When those drugs stop working, the dogma says, it is because cells have developed new cancer-causing mutations that the drugs don't target.
In the new study, however, scientists found that despite having identical genetic mutations, colorectal cancer cells behaved as differently as if they were genetic strangers. The findings challenge the prevailing view that genes determine how individual cells in a solid tumor behave, including how they respond to chemotherapy and how actively they propagate.
If DNA is not the sole driver of tumors' behavior, said molecular geneticist John Dick of the Princess Margaret Cancer Centre in Toronto, who led the study, it suggests that, to vanquish a cancer entirely, drugs will have to target their non-genetic traits too, something few drug-discovery teams are doing.
Genomes are what cutting-edge clinics test for when they try to match a patient's tumor to the therapy most likely to squelch it.
For their study, Antonija Kreso, Catherine O'Brien and other scientists under Dick's direction took colorectal cancer cells from 10 patients and transplanted them into mice. They infected the cells with a special virus that let them track each cell, even after it divided and multiplied and was transplanted into another mouse, then another and another, through as many as five such "passages."
Only one in 10,000 tumor cells was responsible for keeping the cancer growing, the scientists found - in some cases for 500 days of repeated transplantation from one mouse to the next. Genetically-identical tumor cells stopped dividing within 100 days even without treatment.
Tumor cells that were not killed by chemotherapy - the scientists used oxaliplatin, a colon-cancer drug sold by Sanofi as Eloxatin - had the same mutations as cells that were. The survivors tended to be dormant, non-proliferating ones that suddenly became activated, causing the tumor to grow again. Yet the cells - dormant or active, invulnerable to chemo or susceptible - had identical genomes.
"I thought we'd be able to look at the genetics that let some cells propagate, or not be susceptible to chemotherapy, but lo and behold there was no genetic difference," said Dick. "That goes against a main dogma of the cancer enterprise: that if a tumor comes back after treatment it's because some cells acquired mutations that made them resistant."
That's true in some cases, he said, "but what our data are saying is, there are other biological properties that matter. Gene sequencing of tumors is definitely not the whole story when it comes to identifying which therapies will work."
The results were surprising enough, Dick said, that experts reviewing the paper for Science asked him to run additional tests to make sure the cells that behaved so differently were in fact genetic twins. He did, they were, and Science accepted the paper.
Other experts also praised the work, saying it supported the growing suspicion in the field that personalized cancer therapy is oversimplistic, at least in how it's sold to the public.
"It's not as simple as just sequencing mutations to tailor therapies to each tumor," said surgical oncologist Dr. Steven Libutti of the Montefiore Einstein Center for Cancer Care in New York City. "In my mind, the findings are not unexpected. Other things besides genes matter: the environment in which a tumor is growing, for instance, plays an important role in whether therapy will be effective."
Rather than targeting DNA alone, the Toronto scientists suspect, effective therapies would also take aim at what phase of its cycle a cell is in (dormant, growing or dividing, for example), which of its genes are activated, whether it sits in a region of the tumor that is starved of oxygen, and other non-genetic properties.
Nudging tumor cells out of their dormant phase and into their growth cycles, for instance, could make them more susceptible to chemotherapy, which generally targets rapidly dividing cells.
"Our findings raise questions about the resources put into sequence, sequence, sequence," said Dick. "That has led to one kind of therapeutic" - molecularly-targeted drugs - "but not the cures the public is being promised."

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Source: http://www.huffingtonpost.com/2012/12/14/personalized-cancer-medicine-cure-drugs_n_2294867.html

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Easy Web Page Design - samuelfolkes.com - adrianabarsry245s ...

Image of Easy Web Page DesignConsider the case of a simple layout website which is no SEO web design ? there is a header or logo adorning the top of the page followed by a descriptive content, images and links column navigation. These things will make your customers feel safer to purchase from your site. This is the main reason for the website design is not something that should be taken lightly. It should come with free templates for starters give you a base to build on if you do not build your site from scratch. SystemOne native backup functionality of the most GET is a simple CMS that you can save and download your website from the admin area. Therefore, create pages, both in the design of your website that anchor it to a relevant title.
These are the elements that are essential in a website design fully integrated and comprehensive enable these visitors to easy access and evaluate your web page and to establish its credibility and relevance. The Web has also made it easier for companies and business people achieve in a large number of people locally and internationally. Any customization themes must be done manually by an experienced web developer. So spend the time it takes to find top notch software easy web page design will certainly be worth your while in the long term. You do not want to lose customers because people can find the right page on your website to place an order. If a company search engine optimization would ensure the incorporation of keywords and key phrases at the beginning of a web designer is more focused on frills and fancies because he is not aware of serious things.
Also include a link from each page of your website on your order so it will be easy to get every time they make the decision to buy your product. Guidelines before everyone preaches strict naming conventions for optimizing each page and using keywords and hyphens to facilitate exploration of spiders web. A farm All-Australian web design that provides the best website designs on the market. Factors that affect the loading time of the pages may include flash and multimedia applications that you have defined in your page. It should allow you to easily embed forms on your web pages. You just need a base of 10 to 15 page site that is easy to navigate and easy to change.
Only one website can demolish the online business as well. Internet and Businesses Online: Internet-Marketing Both are smart but a little generic, well suited for general business sites. SEO web design can be described as the marriage of two mandatory elements of an online business to know SEO and website design. Internet and Businesses Online: Web-Design There are many design companies website that specializes in providing products and web design services to business people there.
However, it come with some limitations: Make Simple's mission statement asserts its market share "of the small 1-15 page brochure site for the average small business owner substance He who eats the most time, viewers in your site . avoid overpopulation information such as press releases, videos, blogs, articles, forums, comments, songs, stories, news, letters and editorials in a single page. Warranty and advanced supportAnother easy web site design is to include something like a money back guarantee. So look for a software website design that includes a form module to make this process faster and easier. Today it is much more essential for any organization to have a website. Actual expenditures for persons registered with this website design tend to be virtually nonexistent.
The following are reasons why you should choose services WordPress Website Design: There are many WordPress companies that provide development solutions for individuals. Decent CMS theme, but not built in content management systems optionsAll theme to use "themes" or templates (design elements and pooling of all pages). For any web designer to excel in technical SEO web design, there are some tips that should be kept in mind, if the desired success seriously. In conclusion, the most essential point that your web design must have is the integration of relevant context with your product and repairers within. You can choose from their wide range of design software website. And in the same vein, you do not want a web design tool, which is prohibitively expensive or has a steep learning curve that you end up spending weeks or months to learn to use.

Source: http://www.samuelfolkes.com/easy-web-page-design/

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Sounders fans vote to retain GM Hanauer

Associated Press Sports

updated 1:19 a.m. ET Dec. 14, 2012

SEATTLE (AP) - Adrian Hanauer will keep his job as general manager of the Seattle Sounders FC after season-ticket holders and fan alliance members overwhelmingly voted to retain him.

The results of the Sounders' first general manager vote were announced on Thursday night during the organization's yearly meeting. Out of 13,775 total votes, 13,271 were in favor of retaining Hanauer as Seattle's general manager.

The ability for fans to vote to keep or remove the general manager was part of the Sounders' charter when the franchise was created and modeled after a similar structure at FC Barcelona. The vote will take place every four years.

The Sounders also re-signed defenders Jhon Kennedy Hurtado and Patrick Ianni.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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PST: What will Klinsmann do with Bocanegra?

PST: U.S. fans might wish away the harsh realities, hoping against hope that the captain's little hiccups on the field of late were just that ? hiccups. But he'll be 35 by the next World Cup in 2014.

Source: http://nbcsports.msnbc.com/id/50194297/ns/sports-soccer/

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Gun Control Polling: Could Sandy Hook Shooting Shift Support?

WASHINGTON -- Thirteen years ago, the shooting rampage at Columbine High School in Colorado briefly increased support for stricter gun laws, a rise in public favor that soon gave way to a sustained long-term decline. The mass shooting Friday at Sandy Hook Elementary School in Newtown, Conn., which led President Barack Obama to call for "meaningful action," may again shift the polls on gun control.

The Columbine shootings generated more public interest, as measured by the Pew Research Center, than any other news story in 1999. Polls by Pew Research and Gallup conducted in the wake of the tragedy found increases of 6 to 8 percentage points in support for stricter gun laws.

The post-Columbine bump faded about a year later, and support for stricter gun laws remained roughly constant over the next eight years. Following the 2008 election, however, it dropped off considerably. By April 2010, Pew Research found more Americans placed greater importance on protecting the rights of gun owners (49 percent) than on restricting gun ownership (45 percent).

The movie theater shootings in Aurora, Colo., earlier this year did not noticeably shift public opinion. Surveys by both Pew Research and YouGov/Economist after the killings found little or no change in overall attitudes about gun laws.

But the exceptionally horrific details of the Sandy Hook attack -- in particular, the targeting of young children -- raise the possibility of a change in public attitude like the one following the Columbine tragedy. In interpreting the long-term trend, consider the following context:

First, while support for stricter gun laws has declined in the polls across several measures, Americans remain roughly evenly divided on the issue. The Pew Research Center found about equal numbers of Americans preferring to protect "the right to own guns" (46 percent) and to "control gun ownership" (47 percent). A modest increase in the second category would be enough to create majority support for stricter gun laws.

Second, there is broader support among Americans for incremental changes to gun laws. Polls by CNN and YouGov earlier this year found overwhelming support for several specific gun control policies: background checks, bans on gun sales to those with mental health problems, waiting periods before gun purchases and a national registry of gun ownership.

Ariel Edwards-Levy contributed reporting.

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Source: http://www.huffingtonpost.com/2012/12/14/gun-control-polling-sandy-hook_n_2303409.html

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scottcarreey: Courses for Boating | Sports n Recreation Info Center ...

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Climate warming unlikely to cause near-term extinction of ancient Amazon trees, but multiple threats to the forest remain

Dec. 13, 2012 ? A new genetic analysis has revealed that many Amazon tree species are likely to survive human-caused climate warming in the coming century, contrary to previous findings that temperature increases would cause them to die out.

However, the authors of the new study warn that extreme drought and forest fires will impact Amazonia as temperatures rise, and the over-exploitation of the region's resources continues to be a major threat to its future. Conservation policy for the Amazon should remain focused on reducing global greenhouse-gas emissions and preventing deforestation, they said.

The study by University of Michigan evolutionary biologist Christopher Dick and his colleagues demonstrates the surprising age of some Amazonian tree species -- more than 8 million years -- and thereby shows that they have survived previous periods as warm as many of the global warming scenarios forecast for the year 2100.

The paper is scheduled for online publication Dec. 13 in the journal Ecology and Evolution. The new study is at odds with earlier papers, based on ecological niche-modeling scenarios, which predicted tree species extinctions in response to relatively small increases in global average air temperatures.

"Our paper provides evidence that common Amazon tree species endured climates warmer than the present, implying that -- in the absence of other major environmental changes -- they could tolerate near-term future warming under climate change," said Dick, an associate professor of ecology and evolutionary biology and acting director of the U-M Herbarium.

But study co-author Simon Lewis of University College London and the University of Leeds cautioned that "the past cannot be compared directly with the future."

"While tree species seem likely to tolerate higher air temperatures than today, the Amazon forest is being converted for agriculture and mining, and what remains is being degraded by logging and increasingly fragmented by fields and roads," Lewis said. "Species will not move as freely in today's Amazon as they did in previous warm periods, when there was no human influence. Similarly, today's climate change is extremely fast, making comparisons with the past difficult.

"With a clearer understanding of the relative risks to the Amazon forest, we conclude that direct human impacts, such as forest clearance for agriculture or mining, should remain a focus of conservation policy," Lewis said. "We also need more aggressive action to reduce greenhouse gas emissions in order to minimize the risk of drought and fire impacts to secure the future of most Amazon tree species."

Dick and his colleagues used a molecular clock approach to determine the ages of 12 widespread Amazon tree species, including the kapok and the balsa. Then they looked at climatic events that have occurred since those tree species emerged. In general, they inferred that the older the age of the tree species, the warmer the climate it has previously survived.

The researchers determined that nine of the tree species have been around for at least 2.6 million years, seven have been present for at least 5.6 million years, and three have existed in the Amazon for more than 8 million years.

"These are surprisingly old ages," Dick said. "Previous studies have suggested that a majority of Amazon tree species may have originated during the Quaternary Period, from 2.6 million years ago to the present."

Air temperatures across Amazonia in the early Pliocene Epoch (3.6 million to 5 million years ago) were similar to Intergovernmental Panel on Climate Change projections for the region in 2100 using moderate carbon-emission scenarios. Air temperatures in the late Miocene Epoch (5.3 to 11.5 million years ago) were about the same as IPCC projections for the region in 2100 using the highest carbon-emission scenarios.

The 12 tree species used in the study are broadly representative of the Amazon tree flora. Primary forest collection sites were in central Panama, western Ecuador and Amazonian Ecuador. Additional collections were made in Brazil, Peru, French Guiana and Bolivia. Other plant samples were obtained from herbarium specimens.

"The most lasting finding of our study may be the discovery of ancient geographic variation within widespread species, indicating that many rain forest tree species were widely distributed before the major uplift of the northern Andes," said co-author Eldredge Bermingham of the Smithsonian Tropical Research Institute.

To determine the age of each tree species, the researchers extracted and sequenced DNA from plant samples, then looked at the number of genetic mutations contained in those sequences. Using a molecular clock approach and population genetic models, they estimated how long it would take for each of the tree populations to accumulate the observed number of mutations, which provided a minimum age for each species.

"An important caveat is that because we've been in a cold period over the past 2 million years -- basically the whole Quaternary Period -- some of the trees' adaptations to warmth tolerance may have been lost," Dick said. "Additional research is needed to test whether this has occurred."

The Ecology and Evolution paper is titled "Neogene origins and implied warmth tolerance of Amazon tree species." In addition to Dick, Bermingham and Lewis, Mark Maslin of University College London is a co-author. Financial support for the research was provided by the Smithsonian Tropical Research Institute, the University of Michigan, the National Science Foundation and the Royal Society.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/J0vwi-DtuX4/121213192951.htm

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Scary news for corals -- from the Ice Age

Thursday, December 13, 2012

There is growing scientific concern that corals could retreat from equatorial seas and oceans as the Earth continues to warm, a team of international marine researchers warned today.

Working on clues in the fossil coral record from the last major episode of global warming, the period between the last two ice ages about 125,000 years ago, the researchers found evidence of a sharp decline in coral diversity near the equator.

"When the climate warmed rapidly during the Last Interglacial, coral species diversity was much lower close to the Equator than at higher latitudes," says Professor John Pandolfi of CoECRS and The University of Queensland.

"It appears that during this period the number of coral species present in equatorial oceans was only 50-60% of the diversity found further away from the equator, and diversity was greatest in the northern hemisphere."

Professor Pandolfi and his German colleagues found that, when sea surface temperatures warmed by about 0.7 of a degree Celsius during the interglacial warm period, it was enough to drive many species of coral out of equatorial waters up to 10 degrees of latitude on either side of the equator.

"Our results suggest that the poleward range expansions of reef corals occurring with intensified global warming today may soon be followed by equatorial range retractions," the team says in their latest paper, published in the Proceedings of the US National Academy of Sciences.

"Earlier work revealed that the corals had marched as far south as Margaret River in Western Australia during the interglacial ? and we wanted to establish what was happening at the 'hot end' of the corals' range," Prof. Pandolfi explains.

"The answer is, increased temperatures resulted in the extirpation of many coral species in equatorial waters, leading to much poorer reef systems."

What concerns the scientists is that the planet has already warmed by 0.7 of a degree since the start of the industrial age ? a similar amount to the last interglacial ? and while the corals have not yet abandoned equatorial waters, modern equatorial diversity is lower compared to adjacent latitudes north and south.

"If this is the case, it has serious implications for the nations of the Coral Triangle, such as Indonesia and the Philippines, where tens of millions of people rely upon the oceans for their livelihoods and food.

"The picture that is forming is one of corals moving back and forth, towards the poles during warm periods, and retracting towards the equator in cooler times, in search of the most favourable water conditions.

"It is going to be important to factor this kind of dynamism into how we manage them in the hot times which we now know lie ahead."

Prof. Pandolfi has devoted many years to studying major fossilised coral reef deposits around the world most of which are now on dry land ? but which grew in the ocean during warmer periods when sea levels were much higher than today.

"Many of these reefs lie 4-6 metres above today's high tide mark, and are a clear indicator of how much the oceans rose during the last interglacial.

"The thought that just 0.7 of a degree of sea surface warming back then caused a 4-6 metre ocean rise is distinctly disturbing ? because that is how much the Earth has already heated in the current warming episode, and the predictions are for a further one degree or more by 2050.

"Corals, we know, have responded quite readily to rising sea levels in the absence of human stressors. The question will be: can humans respond equally well?"

###

The paper "Equatorial decline of reef corals during the last Pleistocene interglacial" by Wolfgang Kiessling, Carl Simpson, Brian Beck, Heike Mewis and John M. Pandolfi appears in the latest issue of the journal Proceedings of the US National Academy of Sciences (PNAS).

ARC Centre of Excellence in Coral Reef Studies: http://www.coralcoe.org.au/

Thanks to ARC Centre of Excellence in Coral Reef Studies for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/125888/Scary_news_for_corals____from_the_Ice_Age

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Activities for the Elderly on Holiday | BeCleanLiveGreen

Posted by Travel-and-Leisure:Destination-Tips Articles from EzineArticles.com on December 13, 2012

The friendly island of Malta has long been a popular holiday spot and, with a warm and dry climate, this small country caters perfectly to holidaymakers of a more advanced age. Stay near the capital, Valletta, and visit the Casa Rocca Piccola, the home of a noble Maltese family. Showcasing treasures over almost 50 rooms, this mini palace reveals what it's like to live in this compact city, including during World War II when the underground water cisterns were used as air raid shelters......

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